What is Avanafil?
Avanafil, marketed under the brand name
Stendra, is a medication used to treat erectile dysfunction (
ED) in men. It belongs to a class of drugs known as phosphodiesterase type 5 (
PDE5 inhibitors). Avanafil works by increasing blood flow to the penis, helping a man achieve and maintain an erection when sexually aroused.
How Does Avanafil Work?
Avanafil functions by inhibiting the PDE5 enzyme, which is responsible for breaking down cyclic guanosine monophosphate (
cGMP). During sexual stimulation, nitric oxide is released, which enhances the production of cGMP. An increased level of cGMP leads to relaxation of smooth muscles and dilation of blood vessels in the penis, facilitating an erection.
How is Avanafil Administered?
Avanafil is available in oral tablet form and is typically taken as needed. The recommended starting dose is 100 mg, taken approximately 15-30 minutes before sexual activity. Depending on efficacy and tolerability, the dose may be increased to 200 mg or decreased to 50 mg. It is important not to take more than one dose in a 24-hour period. What are the Benefits of Avanafil?
Avanafil offers several benefits over other ED treatments. One of the key advantages is its rapid onset of action, often effective within 15 minutes. This is faster compared to other PDE5 inhibitors like sildenafil (
Viagra) and tadalafil (
Cialis). Additionally, avanafil has a selective action on PDE5, which may result in fewer side effects.
What are the Potential Side Effects?
Common side effects of avanafil include headache, flushing, nasal congestion, and back pain. More serious side effects, though rare, can include sudden vision or hearing loss and an erection lasting more than four hours, known as priapism. Patients experiencing these severe symptoms should seek immediate medical attention.
Who Should Avoid Avanafil?
Avanafil is contraindicated in individuals taking nitrates for chest pain, as this can cause a severe drop in blood pressure. It should also be avoided in patients with severe liver or kidney impairment, and those who have been advised against sexual activity for health reasons. A thorough medical evaluation is recommended before starting avanafil.
How Does Avanafil Compare to Other ED Treatments?
Compared to other ED medications, avanafil has a faster onset and a shorter half-life, which can reduce the duration of side effects. While sildenafil and tadalafil are more established with longer track records, avanafil's rapid action and reduced side effect profile make it a compelling option for many patients.
What are the Considerations for Use?
Before prescribing avanafil, healthcare providers should consider the patient's overall health, existing medications, and potential drug interactions. As avanafil can interact with other medications like alpha-blockers and antihypertensives, a comprehensive review of the patient's medication regimen is crucial.
Conclusion
Avanafil represents a significant advancement in the treatment of erectile dysfunction due to its rapid onset and favorable side effect profile. It is a viable option for men seeking a reliable and quick-acting treatment. However, as with any medication, it is essential for users to consult healthcare professionals to ensure its safety and efficacy in their individual circumstances.
