Glutamate Modulation - Pharma

Relevant Publications

Trigonelline as an anticonvulsant agent: mechanistic insights into NMDA receptor expression and oxidative stress balance.

Issue Release: 2024

Positive allosteric mGluR modulation with BINA alleviates dyskinesia and psychosis-like behaviours in the MPTP-lesioned marmoset.

Issue Release: 2024

Bidirectional modulation of TCA cycle metabolites and anaplerosis by metformin and its combination with SGLT2i.

Issue Release: 2024

Effect of the mGlu positive allosteric modulator biphenyl-indanone A as a monotherapy and as adjunct to a low dose of L-DOPA in the MPTP-lesioned marmoset.

Issue Release: 2024

Structural plasticity of pyramidal cell neurons measured after FLASH and conventional dose-rate irradiation.

Issue Release: 2024

Unlocking the Therapeutic Potential: Sitagliptin\'s Multifaceted Approach in Drug-Resistant Epilepsy through a Novel Mechanism Inhibiting Protein Kinase C-γ and a Long-Term Potentiation Pathway.

Issue Release: 2024

Gut microbiome encoded purine and amino acid pathways present prospective biomarkers for predicting metformin therapy efficacy in newly diagnosed T2D patients.

Issue Release: 2024

Control of astrocytic Ca signaling by nitric oxide-dependent S-nitrosylation of Ca homeostasis modulator 1 channels.

Issue Release: 2024

Alzheimer\'s disease and epilepsy: Research hotspots for comorbidity in the era of global aging.

Issue Release: 2024

Inhibition of Glycyrrhiza Polysaccharide on Human Cytochrome P450 46A1 in vitro and in vivo: Implications in Treating Neurological Diseases.

Issue Release: 2024

Umami Altering Salivary Proteome: A Study across a Sensitivity Spectrum on Subjects.

Issue Release: 2024

Exploring the activation mechanism of metabotropic glutamate receptor 2.

Issue Release: 2024

The Potential of Ambroxol as a Panacea for Neonatal Diseases: A Scoping Review.

Issue Release: 2024

Metabolomic and Lipidomic Analysis of Manganese-Associated Parkinsonism: a Case-Control Study in Brescia, Italy.

Issue Release: 2024

Microbial nitrogen transformation regulates pathogenic virulence in soil environment.

Issue Release: 2024

Gliomagenesis, Epileptogenesis, and Remodeling of Neural Circuits: Relevance for Novel Treatment Strategies in Low- and High-Grade Gliomas.

Issue Release: 2024

Astrocytic glutamate transport is essential for the memory-enhancing effects of 17β-estradiol in ovariectomized mice.

Issue Release: 2024

Perioperative N-acetylcysteine: evidence and indications.

Issue Release: 2024

Group III metabotropic glutamate receptors: guardians against excitotoxicity in ischemic brain injury, with implications for neonatal contexts.

Issue Release: 2024

Conformational basis of subtype-specific allosteric control of NMDA receptor gating.

Issue Release: 2024

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How Does Cellular Stress Impact Drug Development?

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How Can Cellular Stress Be Measured?

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What Strategies do Brand-Name Companies Use to Delay Generic Entry?

What are Adverse Drug Events?

What Challenges Do Pharmacists Face?

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